Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

The rapid identification of respiratory virus outbreaks is needed to enable rational and effective public health interventions. We developed new quantitative approaches for simultaneous ...

Facilities operated by the US Department of Energy (DOE) are required to have extensive worker safety and health programs by regulation. We describe how Argonne National Laboratory (ANL) has ...

File Submission Submit your own Manuscript PDF File—and provide your native LaTeX manuscript package as a ZIP archive. Compress the following into a single ZIP archive (.zip) file: Main body of the ...

The complete biosynthetic pathways of the potent antifungals AS2077715 (1) and funiculosin (2) are reconstituted and characterized. A five-enzyme cascade, including a multifunctional flavin-dependent ...

Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein localization and function in living cells. These hybrid probes are constructed by diverse site-specific ...

Deoxyhalogenation of aryl aldehydes, ketones, carboxylic acids, and esters has been achieved utilizing an appropriate metal halide Lewis acid acting as a carbonyl activator and halogen carrier in ...

Plasmonic nanostructures with hollow interiors have emerged as a class of multifunctional materials for many applications owing to their superior plasmonic activities relative to their solid ...

The cell is a crowded space where large biomolecules and metabolites are in continuous motion. Great strides have been made in in vitro studies of protein dynamics, folding, and protein–protein ...

The atmospheric CO2 concentration has increased significantly since the Industrial Revolution, leading to various environmental issues and energy crisis. The electrochemical reduction of CO2 powered ...

Receptor interacting serine/threonine protein kinase 2 (RIPK2) is a downstream signaling molecule essential for the activation of several innate immune receptors, including the NOD-like receptors ...

Genome editing is a crucial technology for obtaining desired phenotypes in a variety of species, ranging from microbes to plants, animals, and humans. With the advent of CRISPR-Cas technology, it has ...