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生物通
14 小时
POC1A通过STAT3信号通路诱导上皮-间质转化促进三阴性乳腺癌生长与 ...
针对三阴性乳腺癌 (TNBC)高转移性机制不明的难题,研究人员聚焦中心粒蛋白POC1A,通过临床样本分析、RNA测序和动物实验,首次揭示POC1A通过激活STAT3信号通路诱导上皮-间质转化 (EMT),促进TNBC转移。该研究为TNBC治疗提供了新靶点,发表于《Molecular Medicine》。
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