本研究针对老年患者使用阿哌沙班 (apixaban)时肾功能对药物代谢的影响这一临床难题，通过前瞻性观察36名≥65岁急性住院患者，首次揭示严重肾功能不全 (GFR<30 ml/min)患者需减少70%剂量才能避免出血风险。研究采用UPLC-MS/MS精准检测血清浓度，为DOACs个体化用药提供了关键循证依据。

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