Scientists at the University of California, Santa Cruz, have trapped the ribosome, a protein-building molecular machine essential to all life, in a key transitional state that has long eluded ...

A series of structures of the eukaryotic protein-synthesis machinery are imaged at high resolution in defined states of the elongation phase of protein synthesis. Analysis suggests that there are ...

The process of 'translation' in protein synthesis involves formation of a peptide bond between two amino acids that are attached to two distinct transfer RNAs (tRNAs). For long, scientists have been ...

Cryo-EM structure of the Giardia ribosome reveals a highly compact, GC-rich rRNA with eukaryotic r-proteins. (A) Structure of the Giardia ribosome with all the r-proteins colored (SSU, shades of blue ...

The genetic information stored in DNA is “decoded” to form proteins via the process of translation. This involves the formation of peptide bonds between amino acids bound to transfer RNA (tRNA) ...

Scientists from Uppsala University have used cryo-electron microscopy to reveal details of the protein synthesis mechanism in the parasite Giardia intestinalis, which causes diarrhoeal disease. The ...

The research field of 'cellular IRESes' lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...

Ribosomes are composed of two subunits, the small and large subunits, each containing specific rRNA molecules. The main types of rRNA include: Small Subunit rRNA: In prokaryotes, the small subunit ...

Ever since their development in the late 19 th century, Schiff bases have been a popular group of organic compounds, owing to their wide variety of desirable properties. The presence of both nitrogen ...

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at ...