Endocrine therapy typically slows cell cycle progression by reducing cyclin D1, which partners with CDK4/6 to promote cell ...

Engineers have created DIAL, a modular system that precisely sets and edits protein levels in synthetic gene circuits. By ...

By profiling brains from healthy people aged one to 104, researchers found that mutations accumulate in some genes more than ...

Abstract: Gene expression is a pivotal biological process within organisms, and in recent years, the prediction of gene expression levels has garnered increasing attention due to its vast potential in ...

This manuscript is useful as it demonstrates that Rv2577, a Fe³⁺/Zn²⁺-dependent metallophosphatase, is secreted by Mycobacterium bovis BCG and localizes to the nucleus of mammalian cells, altering ...

Abstract: Single-cell RNA sequencing (scRNA-seq) techniques are emerging to revolutionize modern biomedical sciences by providing a detailed landscape of individual cells. However, these methods often ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Loss of p300/CBP decreases the activity of ...