The code is an integral part of the game's plot and you can't beat Madison without opening that lock, but it's not available to open until much, much later, when you'll return to this area after ...

If you ever forget the combination to your bike lock, here's how to open the lock—without any tools required. A word to the wise: You might also consider getting a more secure kind of lock for ...

The Resident Evil 4 code for the Village Chief's Manor cupboard combination lock in is hidden in a text upstairs, a section of a holy book called Iluminados 4:3, where the clues to the lock are found.