Microsoft treats Python in Excel like other embedded scripting languages, automatically blocking them if a document contains a Mark of The Web (MoTW). Windows automatically adds MoTW flags to all ...

Microsoft is integrating Python into its Excel app. A public preview is available for Microsoft 365 subscribers now and all the Python code runs on the Microsoft Cloud.

Python and Excel can only really talk to each other through limited functions—xl () and =PY ()—that can only return code results, not macros, VBA code, or other data, Microsoft claims.