CAR-T 细胞疗法是癌症治疗领域的一项重大突破，也是基因工程细胞作为治疗手段的有力证明。除了已获批准用于白血病等血液类癌症治疗以外，CAR-T 细胞疗法还在实体瘤、自身免疫疾病以及组织再生方面也展现出巨大潜力。 然而，大量临床试验显示，CAR-T 细胞 ...

本综述系统探讨了CRISPR 2.0技术（碱基编辑/先导编辑）在改造T细胞疗法中的突破性应用。通过精准基因编辑可增强T细胞功能 ...

本综述系统探讨了CRISPR-Cas系统在液体活检领域革命性应用。文章详述了如何将Cas9（基因编辑工具）、Cas12a（DNA检测）和Cas13a（RNA检测）与适配体识别、纳米材料富集及杂交链式反应（HCR）、滚环扩增（RCA）等信号放大技术融合，实现对循环肿瘤细胞（CTCs）和 ...

该研究将 CRISPR 激活（CRISPRa）技术应用于 SCN2A 单倍体不足的治疗，在相当于人类 10 岁的青春期小鼠模型中，成功恢复了其大脑中 SCN2A 水平，逆转了神经发育障碍。 大多数单基因诊断的神经发育障碍通过单倍体不足（haploinsufficiency）机制致病，即一个基因的 ...

Researchers from Tel Aviv University have developed a genetic editing method tailored to crop plants, which has influenced various traits in tomato plants, including the taste and shape of the fruit.

When the genome-editing tool CRISPR is thought of as a potential medicine, the targets that first come to mind are diseases like sickle cell or other conditions caused by particular mutations. Use ...

The practice of genetic modification is as old as humanity. For thousands of years, humans have bred crops, livestock and even pets that possess desirable traits. This selective process, which alters ...

With such striking effects, many scientists see modulating the microbiomes as a promising avenue for improving human health and wellbeing. In recent years, researchers have shown that tweaking the ...

Banas is associate director of research at the Gene Editing Institute at ChristianaCare, where Kmiec is founder and executive director. The medical promise of CRISPR gene editing can be seen most ...

A gene called SDR42E1 has been identified as a key player in how our bodies absorb and process vitamin D. Researchers found that disabling this gene in colorectal cancer cells not only crippled their ...