The 7-OH alkaloid is one of the plant's most potent active compounds. According to information distributed by the attorney general, 7-OH levels are low in whole kratom leaves, while isolated or concentrated forms of the compound are much stronger and often are sold as natural or health supplements.

Florida has declared 7-OH, a concentrated kratom byproduct, illegal due to its high potential for abuse and lack of accepted medical use. An emergency rule classifies 7-OH as a Schedule 1 drug, similar to meth and fentanyl, effective immediately.